- Cost of illness of the vaccine-preventable diseases influenza, herpes zoster and pneumococcal disease in France Thu, 07 Dec 2023 06:00:00 -0500
CONCLUSION: Influenza remains a leading vaccine-preventable disease among older adults in France, resulting in a substantial economic burden that could be prevented by increasing vaccine uptake.
- Effect of influenza vaccination on the persistence of HIV reservoirs and immunologic parameters in people with HIV Thu, 07 Dec 2023 06:00:00 -0500
- Harnessing endogenous peptide compounds as potential therapeutics for severe influenza Thu, 07 Dec 2023 06:00:00 -0500
CONCLUSIONS: These findings provide preclinical evidence that therapeutic LAT9997 treatment limits viral burden and characteristic features of severe influenza, including hyperinflammation and lung damage.
- Correlations between COVID-19 cases and temperature, air humidity, and social isolating rate with cross wavelet transform and wavelet coherence: Case study of New York and São Paulo cities Thu, 07 Dec 2023 06:00:00 -0500
The COVID-19 pandemic originated in 2019 and has become an endemic disease that we must learn to live with, similar to other strains of influenza. The Organization (WHO) declared on May 5, 2023, in Geneva, Switzerland, the end of the Public Health Emergency of International Concern regarding COVID-19. As vaccines become more widely available and the pandemic appears to be improved, our focus shifts to the challenges we still face. Understanding how external factors like temperature, air...
- IL-17RA promotes pathologic epithelial inflammation in a mouse model of upper respiratory influenza infection Thu, 07 Dec 2023 06:00:00 -0500
The upper respiratory tract (nasopharynx or NP) is the first site of influenza replication, allowing the virus to disseminate to the lower respiratory tract or promoting community transmission. The host response in the NP regulates an intricate balance between viral control and tissue pathology. The hyper-inflammatory responses promote epithelial injury, allowing for increased viral dissemination and susceptibility to secondary bacterial infections. However, the pathologic contributors to...
- Lung microvascular occlusion by platelet-rich neutrophil-platelet aggregates promotes cigarette smoke induced severe flu Thu, 07 Dec 2023 06:00:00 -0500
Cigarette smoking is associated with a higher risk of ICU admissions among flu patients. However, the etiological mechanism by which cigarette smoke (CS) exacerbates flu remains poorly understood. Here, we show that a mild dose of influenza A virus promotes a severe lung injury in mice pre-exposed to CS but not room air for four weeks. Real-time intravital (in vivo) lung imaging revealed that the development of acute severe respiratory dysfunction in CS and flu exposed mice was associated with...
- Review of the potential pharmacological role of erucic acid: a monounsaturated omega-9 fatty acid Thu, 07 Dec 2023 06:00:00 -0500
This comprehensive review aims to provide an overview of the pharmacological properties of erucic acid (EA) and highlight areas that require further research. EA is an omega-9 fatty acid found in certain vegetable oil, such as rapeseed oil has demonstrated favourable effects in rodents, including ameliorating myocardial lipidosis (fat accumulation in the heart muscle), congestive heart disease, hepatic steatosis (fat accumulation in the liver), and memory impairments. These findings have...
- Optimizing mood prior to influenza vaccination in older adults: A three-arm randomized controlled trial Thu, 07 Dec 2023 06:00:00 -0500
CONCLUSIONS: Brief psychological interventions can improve mood prior to vaccination. However, altering antibody responses to highly immunogenic adjuvanted vaccines may require more targeted or prolonged interventions. The provision of choice did not notably enhance the interventions impact on mood or antibody outcomes. (PsycInfo Database Record (c) 2023 APA, all rights reserved).
- Age-specific resurgence in invasive pneumococcal disease incidence in the COVID-19 pandemic era and its association with respiratory virus and pneumococcal carriage dynamics: a time series analysis Thu, 07 Dec 2023 06:00:00 -0500
Using multiple national surveillance systems, we found an increase in invasive pneumococcal disease (IPD) incidence in the early post-COVID-19 pandemic period that strongly varied by age. Age-groups with higher incidence of respiratory syncytial virus and influenza also experienced higher increase in IPD incidence, with no change in pneumococcal carriage.
- Time to treat the climate and nature crisis as one indivisible global health emergency Thu, 07 Dec 2023 06:00:00 -0500